In the case of antiresorptive agents—medicines that help strengthen bones—these
medications have been associated with a rare but serious condition called osteonecrosis
that can cause severe damage to the jawbone.
Some antiresorptive agents, such as Fosamax, Actonel, Atelvia, Didronel and Boniva,
are taken orally to help prevent or treat osteoporosis (thinning of bone) and Paget's
disease of the bone, a disorder that involves abnormal bone destruction and re growth,
which can result in deformity. Other antiresorptive agents, such as Boniva IV, Reclast
or Prolia, are administered by injection. Higher and more frequent dosing of these
agents is given as part of cancer therapy to reduce bone pain and hypercalcemia
of malignancy (abnormally high calcium levels in the blood) associated with metastatic
breast cancer, prostate cancer and multiple myeloma.
While osteonecrosis of the jaw can occur spontaneously, it more commonly occurs
after dental procedures that affect the bone or associated tissues (for example,
pulling a tooth).
The IDA recommends that you should tell your dentist if you are taking antiresorptive
agents so he or she can take that into account when developing your treatment plan.
Eat a diet rich in calcium, even if you are taking medication, and ask your doctor
whether or not you should take calcium and vitamin D supplements.